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Filtered Search Results
![eMolecules 4510-76-3 | 2,4-Quinolinediol monosodium salt | Combi-Blocks | MFCD00078382 | 183.142 | C9H6NNaO2 | 97.000 | [Na+].Oc1cc([O-])nc2ccccc12 | 1g | 448009166](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502185739.JPG-250.jpg)
eMolecules 4510-76-3 | 2,4-Quinolinediol monosodium salt | Combi-Blocks | MFCD00078382 | 183.142 | C9H6NNaO2 | 97.000 | [Na+].Oc1cc([O-])nc2ccccc12 | 1g | 448009166
2,4-Quinolinediol monosodium salt | Combi-Blocks | 4510-76-3 | MFCD00078382 | 183.142 | C9H6NNaO2 | 97.000 | [Na+].Oc1cc([O-])nc2ccccc12 | 1g | 448009166
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eMolecules 860205-92-1 | 7-Bromo-4-hydroxyquinoline-3-carboxylic acid | Apollo Scientific | MFCD02684222 | 268.066 | C10H6BrNO3 | 95.000 | OC(=O)c1cnc2cc(Br)ccc2c1O | 1g | 562462421
7-Bromo-4-hydroxyquinoline-3-carboxylic acid | Apollo Scientific | 860205-92-1 | MFCD02684222 | 268.066 | C10H6BrNO3 | 95.000 | OC(=O)c1cnc2cc(Br)ccc2c1O | 1g | 562462421
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eMolecules 77717-71-6 | 6-HYDROXYQUINOLINE-5-CARBALDEHYDE | AstaTech | MFCD11869102 | 173.171 | C10H7NO2 | 98.000 | Oc1ccc2ncccc2c1C=O | 0.1g | 633668236
6-HYDROXYQUINOLINE-5-CARBALDEHYDE | AstaTech | 77717-71-6 | MFCD11869102 | 173.171 | C10H7NO2 | 98.000 | Oc1ccc2ncccc2c1C=O | 0.1g | 633668236
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Medchemexpress LLC Pictilisib (dimethanesulfonate) | 957054-33-0 | 99.7% | 705.85 | 200 MG
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Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
- Potent inhibitor of PI3Kα/δ with IC50 of 3 nM
- Modest selectivity against p110β (11-fold) and p110γ (25-fold)
- Reduces tumor cell viability in breast cancer cell lines
- Inhibits Akt phosphorylation and downstream targets of Akt signaling
- Shows high efficacy of antitumor activity in ZD1839-resistant non-small cell lung cancer (NSCLC) cell lines (A549 and H460)
- Highly efficacious in combination with U0126 in inducing cell growth inhibition, G0-G1 arrest, and cell apoptosis
- Reduces secreted VEGF after hypoxic/anoxic exposure
- Leads to tumor stasis in animal models
- Results in tumor regressions during treatment leading to enhanced antitumor responses
- Reduces tumor growth and PI3K and HIF-1 pathway activity in tumor-bearing mice
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TARGETMOL CHEMICALS INC NITROCEFIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Nitrocefin is an antibiotic. It being sensitive to hydrolysis by all lactamases produced by gram-positive and gram-negative bacteria. purity: 98%
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Apexbio Technology LLC AZ5104 1421373-98-9 200mg
AZ5104 (CAS 1421373-98-9) is a demethylated metabolite of AZD9291 functioning as a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase It exhibits high affinity for mutant EGFR forms with IC50 values below 1 nM for EGFR L858R/T790M 6 nM for EGFR L858R 1 nM for EGFR L861Q and 25 nM for wild-type EGFR Compared to AZD9291 AZ5104 demonstrates increased potency in cellular models harboring EGFR ex19del (PC-9) T790M (H1975) and wild-type EGFR (LOVO) In vivo oral administration in mice led to a plasma metabolite level of 33% at 3 hours post-dose and 5 mg/kg/day reduced tumor growth in relevant models AZ5104 serves as a valuable tool for studying EGFR-driven cancer mechanisms and resistance
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TARGETMOL CHEMICALS INC MOXIDECTIN 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Moxidectin (CL301423) is an anthelmintic drug which kills parasitic worms and is used for the prevention and control of heartworm and intestinal worms. It can be found in treatments prescribed for animals such as dogs cats horses cattle and sheep. Application methods for moxidectin vary by treatment and include oral topical and injectable solutions. Cydectin Pour On is a trade name for a formulation for use on cattle and red deer. purity: 99%
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TARGETMOL CHEMICALS INC LY2940094 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective selective and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). purity: 99%
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Medchemexpress LLC Branaplam | 1562338-42-4 | 98.90% | 393.48 | 200 MG
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Branaplam is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. It inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- Highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator.
- Elevates full-length SMN protein.
- Extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- EC50 of 20 nM for SMN.
- IC50 of 6.3 μM for hERG.
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Apexbio Technology LLC Regorafenib hydrochloride(Synonyms: Regorafenib HCl, BAY 73-4506, Stivarga, BAY73-4506 hydrochloride, Regorafenib hydrochloride salt), 200mg, CAS: 835621-07-3.
Regorafenib hydrochloride (CAS 835621-07-3) is an orally bioavailable small molecule inhibitor targeting multiple protein kinases including c-KIT VEGFR2 and B-Raf It inhibits these kinases with IC50 values of approximately 17 nM (c-KIT) 40 nM (VEGFR2) and 69 nM (B-Raf) By blocking kinase signaling Regorafenib hydrochloride effectively interrupts tumor-associated pathways involved in cell proliferation angiogenesis and survival It is widely used in oncology research for studies focused on kinase-mediated tumor growth and vascularization mechanisms
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Apexbio Technology LLC Nucleozin 341001-38-5 200mg
Nucleozin (CAS 341001-38-5) is a small-molecule inhibitor targeting influenza A virus nucleoprotein (NP) It is designed to block NP nuclear accumulation thereby inhibiting a critical step in the viral replication cycle Nucleozin exerts its biological activity primarily through inducing NP aggregation and preventing its nuclear localization In in vitro studies using MDCK cells infected with influenza A variants Nucleozin demonstrates antiviral inhibition with EC50 values of 0 069 M for A/WSN/33 (H1N1) 0 16 M for H3N2 and 0 33 M for Vietnam/1194/04 (H5N1) Based on these pharmacological properties Nucleozin holds research potential in influenza antiviral development
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Medchemexpress LLC Guanidinoethyl sulfo 25mg | 25MG
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Guanidinoethyl sulfo 25mg | 25MG
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Apexbio Technology LLC SB743921 940929-33-9 200mg
SB743921 (CAS 940929-33-9) is a potent and selective inhibitor of kinesin spindle protein (KSP) exhibiting a Ki of 0 1 nM for human KSP and 0 12 nM for mouse KSP with negligible affinity for other kinesins By targeting KSP SB743921 disrupts mitotic spindle formation leading to cell cycle arrest and apoptosis In cellular assays SB743921 demonstrates strong antiproliferative activity against SKOV3 Colo205 MV522 and MX1 cell lines with IC50 values ranging from 0 02 to 1 7 nM Additionally it shows efficacy in multiple human tumor xenograft models and in a murine P388 lymphocytic leukemia model SB743921 is utilized in oncology research for mechanistic studies and therapeutic evaluation of mitotic inhibition
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![Medchemexpress LLC (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile | 109511-58-2 | 98.6% | 200MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233976.png-250.jpg)
Medchemexpress LLC (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile | 109511-58-2 | 98.6% | 200MG
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(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile | 109511-58-2 | 98.6% | 200MG
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Medchemexpress LLC WY 49051 200 mg
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WY 49051 200MG
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